Endocrine Abstracts

Introduction/background: Hypothalamic Amenorrhea (HA), or stress-induced anovulation, is one of the most common causes of secondary amenorrhea (1,2) and accounts for the reproductive dysfunction seen in under nutrition, excessive exercise, sever emotional stress and chronic disease. From a teleological standpoint, in the face of nutritional or physical stress, it is adaptive for an organism to allocate energy resources for its own survival rather than the costly process of rep...

Background: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognised disorder with an estimated prevalence of 20–30% in the general population and is considered as the hepatic manifestation of the metabolic syndrome. Fatty liver index (FLI) has been developed as an indicator of hepatic steatosis (HS). Another marker, the lipid accumulation product (LAP) index, initially developed to assess cardiovascular risk, has been recently shown to be a reliable marker ...

Background: Increased prevalence of abnormal aminotransferase levels and/or ultrasonographic evidence of hepatic steatosis have been found in women with polycystic ovary syndrome (PCOS), being more pronounced in overweight and obese patients. However, few data exist concerning the prevalence of PCOS in premenopausal women with nonalcoholic fatty liver disease (NAFLD).Objective: To investigate the presence of PCOS in overweight and obese premenopausal wom...

Introduction/Background: ACTH production from a midgut mesentery NET is extremely rare (1). A 62y old woman presented with hypokalaemia (2mmol/L) and hyperpigmentation, 11y after surgery of a pT3N1Mx non-functional G1 NET with SRS positive, non-resectable but stable, residual mass encasing mesenteric vessels. Serum cortisol (3261 nmol/L), ACTH (796 ng/L), CgA (530 pmol/L) and urine total cortisol metabolites (33920 μg/24h) including 14 sub-products indicated change of bio...